129/SvJ mice have mutated CD23 and hyper IgE

معرفی یک مورد سندرم ازدیاد Hyper-IgE Syndrome) IgE)

Hyper IgE syndrome (Job’s syndrome) is a primary immunodeficiency disease with recurrent infections especially staphylococcal, coarse face, skeletal abnormality and significant increase in serum IgE level (IgE >2000IU/ml). We present a 16 years old boy admitted with chronic cough, dyspnea, eczema and pneumatocele. He had a history of chronic dermal infection since 1 month after birth. The dia...

گزارش تظاهرات ریوی در سندرم Hyper IgE

سابقه و هدف: سندرم Hyper IgE بیماری نادری از دسته سندرم‌های کمبود ایمنی اولیه است که با مشخصات عفونت‌های ریوی و جلدی، اگزما و افزایش سطح سرمی IgE مشخص می‌شود. در این مقاله، 4 بیمار مبتلا به عفونت‌های متعدد ریوی در زمینه سندرم Hyper IgE. معرفی می‌گردند. معرفی مورد: در این مطالعه 4 دختر که سابقه عفونت‌های ریوی متعدد داشتند، بررسی شدند و در نهایت سندرم Hyper IgE در آنها تشخیص داده شد. در تمامی ...

Hyper-IgE syndrome

Restoration of the antibody response to IgE/antigen complexes in CD23-deficient mice by CD23+ spleen or bone marrow cells.

Mice immunized with IgE/Ag complexes produce significantly more Ag-specific Abs than mice immunized with Ag alone. The enhancement is mediated via the low-affinity receptor for IgE (FcepsilonRII or CD23), as shown by its complete absence in mice pretreated with mAbs specific for CD23 and in CD23-deficient mice. Because the constitutive expression of murine CD23 is limited to B cells and follicu...

Uncoupling of Natural IgE Production and CD23 Surface Expression Levels

CD23, the low affinity receptor for immunoglobulin E (IgE), has been proposed to play a critical role in the regulation of IgE production, based on altered IgE levels in CD23-deficient mice and transgenic mouse models, as well as in mouse strains with mutations in the CD23 gene, e.g. 129 substrains. Here, we have investigated a mouse line termed LxT1 that expresses reduced CD23 surface levels o...